My Canadian Pharmacy: Asthma Types

My Canadian Pharmacy: Asthma Types

Bronchial asthma is chronic inflammatory disease of upper respiratory tract, primarily of bronchi, in which patient occasionally has suffocation attacks. There are different myths and facts about asthma, about which you may read here — https://mycanadianpharmacyteam.com/myths-about-asthma.html. But first of all it is necessary to determine asthma types.

Asthma Types

There are three main asthma types. They are:

  1. atopic;
  2. infectious-allergic asthma;
  3. medicinal asthma.

Atopic Asthma

Atopic asthma is caused by body’s reaction to allergens as my canadian pharmacy online points out, most often through inhalation, that is, those that people inhale. They are:

  • dust mite;
  • pollen;
  • spores of mold fungi;
  • animal hair.Asthma Types

A little less often asthma can cause food allergens.

When they enter body, allergic reaction is triggered, which manifests itself by narrowing bronchial lumen and producing thick mucus in them, which makes breathing more difficult. If contact with allergen does not occur, person feels well.

Often such type of asthma is combined with other allergic manifestations, for example, with rhinitis or dermatitis. This form is common in young children.

Infectious-allergic Asthma

Infectious-allergic asthma develops on the background of chronic infection in respiratory tract. It can be bronchitis, sinusitis and tonsillitis which are not fully treated. Constant inflammation, presence in body of foreign bacteria and products of their vital activity leads to changes in bronchi. They become more sensitive to all kinds of irritants, local immunity is violated. As a result, it leads to asthmatic attacks. This type of asthma is rarely seen in children, mainly it occurs in people 35-40 years and older.

Medicinal Asthma

Medicinal asthma is the result of certain medications use. It is associated with individual reaction to particular drug (or its component). These drugs are primarily aspirin and non-steroidal anti-inflammatory drugs, so this type of asthma is often called aspirin.

The main manifestation of asthma — suffocation attacks — it is impossible not to notice. However, there is atypical variant of asthma, it is called cough. Strong breathing difficulties are not observed, but there is dry obsessive cough.

Such type of asthma is often confused with bronchitis, but it should be treated in different way. Therefore, do not put on experiments — consult a doctor and take a survey.

To identify asthma, in addition to usual breathing examination with stethoscope, number of studies are required. These are:

  • measurement of expiratory flow rate;
  • vital capacity of lungs;
  • chest X-ray.

Important

Bronchial asthma is disease that is really controlled. To do this, you need to have at hand my canadian pharmacy inhaler, which is used for attacks, and carry out treatment in quiet periods, when there are no symptoms. Such therapy is aimed at eliminating inflammation in respiratory tract. For it, hormones glucocorticosteroids are used in form of aerosol inhalers.

It is also important to identify root cause of seizures and, if possible, to eliminate it:

  • avoid contact with allergens;
  • treat infection of respiratory tract;
  • adjust treatment with nonsteroidal anti-inflammatory drugs.

Every patient with bronchial asthma should have device for self-monitoring — peakflowmeter. It is small tube with scale that shows exhalation rate in liters per minute. The indicators of peakflowmeter change before health state worsens. Therefore, it is possible to take timely measures, adjust treatment and prevent an attack.

Consideration of Proteomic Analysis of Peripheral T-Lymphocytes in Patients With Asthma

T-lymphocytesThis is the first proteomic approach using the human T-lymphocytes of blood in asthmatic patients. Although the proteomic data of the T-lymphocytes of normal human has been reported, no study on T-lymphocytes in asthmatic patients has been reported.

It is known that the asthmatic process that triggers the immune system can lead to excessive release of various cytokines and inflammatory mediators, which are produced by T-cells, infiltrated mononuclear cells, eosinophils, and local mast cells into the lung. Among the inflammatory cells, T-lymphocytes play major roles in the pathogenesis of bronchial asth-ma.’ So, we performed proteomic analysis of the peripheral T-lymphocytes of asthmatic patients.

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My Canadian Pharmacy about Outcomes of Proteomic Analysis of Peripheral T-Lymphocytes in Patients With Asthma

My Canadian Pharmacy about Outcomes of Proteomic Analysis of Peripheral T-Lymphocytes in Patients With Asthma

MALDI-TOF-MS2D-PAGE

More than 300 spots were identified in the 20-PAGE gels from the T-lymphocytes of the normal and asthmatic patients. The general distribution pattern of the spots in the silver-stained gels was similar in both groups (Fig 1, top left, A, and top right, B). The spots in the area of pi 4 to 7, and molecular weight of 20 to 100 kd were analyzed by an image analysis program (ProteomWeaver). Protein spots of the normal and asthma groups were compared, and 25 proteins showed different intensity, suggesting the differential expression. Among them, the intensities of 13 spots were significantly increased and the intensities of 12 spots were decreased in the asthma group compared to the control group. The 25 selected spots of the 2D-PAGE of an asthmatic, nonsmoking, 27-year-old man are shown in Figure 1, bottom, C.

Identification of the Differentially Expressed Proteins by MALDI-TOF-MS

After destaining, extraction, and lysis with trypsin, the individual spots were identified by MALDI-TOF-MS and this was followed by a database search (MS-FIT). On the list of 20 candidate proteins for each spot, the final protein was determined by comprehensively considering the corresponding experimental isoelectric point, the molecular masses, the number of matched peptides, and the sequence coverage. Thirteen up-regulated and 12 down-regulated proteins in the asthmatic group were identified (Table 1). Testing for multiple comparisons by FDR analysis resulted in an FDR threshold (a) value of 0.0396468. Treat asthma and read more about it on My Canadaina Pharmacy – https://mycanadian-pharmacy.net/category/asthma.

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Proteomic Analysis of Peripheral T-Lymphocytes in Patients With Asthma

Proteomic Analysis of Peripheral T-Lymphocytes in Patients With Asthma

Systemic steroidStudy Subjects

Six patients with asthma were enrolled (three men and three women; mean age, 28 years). Asthma was diagnosed according to the criteria of the American Thoracic society. All asthmatic patients were nonsmokers, and two of the asthmatic patients had atopy. None of the patients with asthma had complications from other lung disease, and they did not have a history suggesting systemic viral infections, tumors, or autoimmune diseases. Systemic steroid was not used in asthmatic patients during the previous 3 months.

Six healthy volunteers (two men and four women; mean age, 26 years) were enrolled from graduate students at the College of Medicine, Korea University, and served as control subjects. All control subjects were nonsmokers and had normal findings on chest radiography, normal airway reactivity, and normal pulmonary function test results; and they had no current respiratory symptoms, were nonatopic, and had no respiratory infections within the previous month. None were receiving any medications. Informed consents were obtained from each subject for their participation in the study, and the approval of the protocol was obtained by the Clinical Research Ethics Committee of Korea University Medical Center.

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Asthma May Raise Risk for Abdominal Aneurysm

Asthma May Raise Risk for Abdominal Aneurysm

People 50 and older who have had recent asthma activity appear to be at an increased risk of abdominal aortic aneurysm, a new study suggests.

An abdominal aortic aneurysm is a weak spot in the body’s main artery, the aorta, where it passes through the abdomen. That weak spot can rupture, causing massive bleeding. The researchers also found that people with recent asthma activity were more likely to have an aneurysm rupture compared to those without recent asthma activity.

“People with abdominal aortic aneurysm who were diagnosed with asthma within the past year had more than a 50 percent greater risk of ruptured aneurysms than those without asthma,” said lead researcher Guo-Ping Shi, from Brigham and Women’s Hospital in Boston.

Men diagnosed with asthma within the preceding six months were twice as likely to have an aortic aneurysm rupture, Shi said, adding that the risk was much lower among women.

Read on http://www.medicinenet.com/script/main/art.asp?articlekey=193646.

My Canadian Pharmacy about Asthma in Puerto Rican Children

 multivariable analysisFigure 1 shows the schema for enrollment into the study by individual study site. Based on the sampling design, a total of 21,185 households were randomly selected for inclusion in the study; 20,681 households (97.6%) were successfully contacted. Of these 20,681 households, 1,853 households (9.0%) with 2,940 children were eligible for the study. However, 449 of 2,940 eligible children did not participate in the study because of parental refusal or repeated unavailability (three or more unsuccessful attempts). The final study population consisted of 2,491 children in 1,643 households. There were households with one (n = 1,009), two (n = 420), and three (n = 214) eligible children.

Table 1 summarizes the characteristics of the study population. The denominator indicates the number of participants who provided valid information; missing values and “don’t know” were excluded from the calculations. Site of residence and birthplace were highly correlated: 90.2% of participants living in the Bronx were born in the mainland United States, and 94.6% of those living in Puerto Rico were born in Puerto Rico. Children living in Puerto Rico were more likely to have four grandparents who were born in Puerto Rico than Puerto Rican children living in the South Bronx. Families of Puerto Rican children in Puerto Rico were more likely to have household incomes < $25,000 per year but less likely to receive public assistance in the past year than families of Puerto Rican children in the South Bronx. Mothers of Puerto Rican children in Puerto Rico were more likely to have completed high school (HS) or a general equivalency diploma (GED) and less likely to smoke during pregnancy than mothers of Puerto Rican children in the South Bronx. Premature birth was lower in Puerto Rican children in Puerto Rico than in Puerto Rican children in the Bronx.

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Studying of Area of Residence, Birthplace, and Asthma in Puerto Rican Children

mental illnessThis was a population-based prospective cohort study of the prevalence of antisocial behaviors and associated comorbid conditions (eg, asthma) among Puerto Rican children in each of two sites. Children in the South Bronx (New York) and the standard metropolitan areas of San Juan and Caguas (Puerto Rico) were enrolled from July 2001 through August 2003. The study was approved by the Institutional Review Boards of the New York State Psychiatric Institute and the University of Puerto Rico Medical School.

The study employed a multistage probability sample design described in detail elsewhere. Briefly, primary sampling units were randomly selected neighborhood clusters based on the 1990 US Census and subsequently adjusted to the 2000 census. Secondary sampling units were randomly selected households within each individual primary sampling unit. To contrast the prevalence of antisocial behaviors between island and mainland Puerto Rican children (the primary purpose of the original study), the sample size was calculated to be 1101 children per site in order to detect a risk ratio of 1.5 with 80% power at a p value <0.05.

A household was eligible if as follows: (1) at least one resident was a child between the ages of5 and 13 years who was identified by his/her parents/primary caretakers as being of Puerto Rican background, and (2) at least one of the child’s parents or primary caretakers in the household also self-identified as being of Puerto Rican background. In households with more than one eligible child, a maximum of three children were randomly selected to participate. Children were not eligible if they had mental retardation or developmental disabilities, or if they had not resided in the household for at least 9 months. Continue reading “Studying of Area of Residence, Birthplace, and Asthma in Puerto Rican Children”