In various forms of pulmonary hypertension, an association between elevated pulmonary artery pressures and abnormal left ventricular (LV) diastolic function has been proposed. Ventricular interaction with a shift of the septum toward the LV as a consequence of right ventricular pressure overload has been suggested as the primary cause of LV diastolic dysfunction.
At high altitude, not only acute hypoxia-induced pulmonary hypertension but also changes of the transmitral inflow pattern suggestive of impaired LV diastolic function have been described. In accordance to chronic right-sided pressure overload, ventricular interaction has been discussed as a cause for the observed alteration in LV diastolic function. Recently, a new concept of compensated altitude-induced diastolic dysfunction was proposed because changes in diastolic function at high altitude were mainly related to an increase in the atrial phase of LV filling.