My Canadian Pharmacy: Antiviral Agents

Canadian Pharmacy antiviral agents are increasingly prescribed by doctors under certain conditions and are used in home practice for self-treatment by people. What kind of preparations are these, are they effective and harmless, whether or not to use them? Maybe it is better to return to traditional home remedies – garlic, onions, lemon, milk and honey? After all, they are long used to effectively treat «colds», infectious and viral diseases, accompanied by decrease in immunity?

Mechanism of Antivirals Action

Antiviral drugs are isolated from anti-infective medicines in a separate group. This is done due to the fact that no other antibacterial agents (including known antibiotics) are able to provide effective influence on virus growth. This invulnerability of viruses is connected to their small and special structure. For instance, try to compare, say, size of our planet and apple. So, planet in our example is a medium-sized germ, and apple – a virus.

canadian pharmacy antivirals

Viruses consist of nucleic acids – sources of information for self-reproduction, and surrounding them capsules. In the body of «master» they can, under favorable conditions, multiply very quickly, including by means of «embedding» of their information in patient’s body cells, which themselves begin to recreate these pathogenic form. Traditional defenses of human immunity (blood cells) are often powerless before them. According to My Canadian Pharmacy data, the number of pathogenic viruses found is more than 500.

The first drug with antiviral properties was obtained in far 1946, it was named thiosemicarbazone. As main component, it was a part of Faringosept, and for many years has been used in clinical medicine to fight inflammatory diseases of throat. Then idoxuridine was created, which is used against herpes virus.

Note: break trough in virology was finding of human interferon – protein that suppresses vital activity of viruses.

Since beginning of 80s of the last century active work on creation of drugs that stimulate ability of interferon synthesis began. Scientific work continues in our time. Unfortunately, antiviral drugs cost is quite high. Alas, on pharmaceutical market today, there is a large number of fakes – drugs that do not have protective or stimulating properties, in fact, «dummy pills».

Types of Antivirals

All available antiviral drugs can be divided into 2 groups:

  1. immunostimulants – drugs that can for a short time dramatically increase production of interferons.
  2. antivirals – medicines that have direct inhibitory effect on virus and block its reproduction.

According to action on different types of viruses there distinguish:

  • antiviral drugs with effect on influenza viruses;
  • drugs against herpes virus;
  • agents that inhibit activity of retroviruses;
  • anti-cytomegalovirals.

Note: You can individually select a group of drugs for HIV treatment (Human Immunodeficiency Virus).

Diagnosis – «High Cholesterol»

High cholesterol clogs blood vessels and is able to cause heart attack or blood stroke. So the sooner you will know how to control level of this substance, the better.

Why cardiologists recommend to all without exception to monitor cholesterol level? Man is mortal and, as Woland said, sometimes he is suddenly mortal. The leadership among diseases in «death» discipline is held by cardiovascular diseases and the most powerful of them – myocardial infarction. If you do not know mechanics of the latter, My Canadian Pharmacy informs: due to cholesterol plaques, lumen of blood vessels, that feed heart, narrows – and there blood clot easily «settles» which stops blood flow to myocardium (heart muscle). The larger volume remained without nutrition, the less chance of survival there are.

cholesterol level and how to control it

And now about the good. About cholesterol. After all, in this world there is almost no pure «evil». The subject of our conversation by nature intended to be a building material of our organism. Cell membranes in the body are made of cholesterol, it is the basis of almost all hormones. So it is important to us and helpful – as long as its content in the body is balanced. But in some cases, this substance becomes a murderer, so let’s find out how to «disarm» it.

Bad and Good Cholesterol

Not so much quantity of the substance in the blood is important as ratio of its «good» and «bad» emanations. «Bad» cholesterol is called substance of low and very low density. If you undergone biochemical analysis of blood, in the form with results it will be referred to as acronym VLDL and LDL (very low-density lipoprotein and low-density lipoprotein). These 2 types of cholesterol can be deposited on walls of arteries.

«Good» is their opponent. Its task is to collect excess bad cholesterol in the body, and send it to liver for re-melting. In analyzes it is referred to as HDL (high density lipoprotein).

The conclusion is clear: the more «good» in blood, the purer vessels are and longer life is. Doctors called excess HDL «longevity syndrome». This happens, for example, with mountain peoples of Caucasus: simply because of their hereditary liver produces so much high-density lipoprotein that they die in their old age and almost healthy.

Causes of High Cholesterol

Perhaps you’ve heard that we should eat properly to maintain balance of cholesterol in blood: less animal fat, no fat and butter, more plant food – and the trick is done. In fact, 80% of material produced in liver and only 20% comes from food.

Synthesis of cholesterol in liver is affected by many factors, as My Canadian Pharmacy experts say. First of all – health of the body, plus hereditary factor, stress and human ability to cope with it, thyroid condition.

If you drink, smoke, breathe impure air of cities (destroying liver) plus working hard – then even if heredity is perfect excess «bad» cholesterol can be observed in blood. Conversely, at healthy eating, sports achievements and staying in Bali, bad genetics can ruin the whole picture.

What to Do with Cholesterol

Cholesterol does not need to be treated with medications, and even more so surgically, if it narrows vessel lumen by less than 60%. In this case, the main task is to prevent spread. Here’s how it’s done.

  • Fatty, salty, sweet foods, fried potatoes with bacon – all terribly unhealthy is banned. Especially important to limit fats of animal origin.
  • Do not fall into fanaticism: completely fat-free products are not less evil for metabolism than pure fat.
  • Do not believe those who say that you should eliminate from your life meat to lower cholesterol levels.
  • Fish for help! It is this product that gives us wonderful opportunity to raise level of «good» cholesterol in blood.
  • It is believed that in fight against cholesterol – seafood is useful. As it turns out, not all seafood: loricates – prohibited, shelly – allowed.
  • Go in for sports.
  • For the sake of liver health, of course, you should not drink and smoke.

Serious Treatment

If plaques cover vessels by 60% or more, it is time to reflect on serious treatment. To date, there are 2 main methods: drugs for cholesterol (statins) and stenting.

Statins reduce production of «bad» cholesterol in liver, which allows to stop formation of plaques and seal them, improving blood flow.

cholesterol control with My Canadian Pharmacy

Stenting is a surgical manipulation. A stent is a plastic tube with metal frame, which is installed in a vessel. This is done in a tricky way: through a puncture in femoral artery. From there, folded stent is inserted into small balloon, «pushed» to any trouble area. On the spot in blocked artery, the balloon is inflated, stent is inserted into it straightens and flattens cholesterol plaques. Since then, patient lives with a kind of prosthesis, to prop up vascular wall. More recently there were invented stents that dissolve over time.

Naturally, any statin or stenting alone are not prescribed independently: such treatment is preceded by a variety of medical examinations and detailed analysis of situation.

Pathogenesis and Natural History of Usual Interstitial Pneumonia: Pathology of IPF

Pathogenesis and Natural History of Usual Interstitial Pneumonia: Pathology of IPF

Idiopathic interstitial pneumoniasIdiopathic interstitial pneumonias are a heterogeneous group of diffuse parenchymal lung disorders resulting from damage to the lung parenchyma by varying patterns of inflammation and fibrosis. In 2002, the American Thoracic Society/European Respiratory Society classified1 idiopathic interstitial pneumonias into seven distinct entities based on clinical manifestations, pathology, and radiologic features (Table 1). One of these entities, idiopathic pulmonary fibrosis (IPF), is a progressive, fatal disease. IPF has been defined in an American Thoracic Society/European Respiratory Society consensus statement1 as a type of chronic fibrosing interstitial pneumonia of unknown etiology that is limited to the lungs and is associated with surgical biopsy specimens showing a histologic pattern of usual interstitial pneumonia (UIP). UIP histopathology is not unique to IPF, and has been reported in asbestosis, chronic hypersensitivity pneumonitis, and collagen vascular disorders with associated interstitial lung disease.

While ongoing research continues to investigate multiple hypotheses of UIP pathogenesis, neither the natural history nor the pathogenesis of UIP is currently well understood. To determine whether UIP represents the end stage of IPF, it is important to elucidate the complete natural history and pathogenesis of IPF, which would allow the investigation of potentially different mechanisms that may be operative at the early, intermediate, and end stages of the disease. This knowledge could lead to the implementation of targeted therapeutic interventions at specific stages of the disease process. Continue reading “Pathogenesis and Natural History of Usual Interstitial Pneumonia: Pathology of IPF”

Disscusion of The Beneficial Effect of Alcohol Consumption on the Prevalence and Extent of Centrilobular Emphysema

Disscusion of The Beneficial Effect of Alcohol Consumption on the Prevalence and Extent of Centrilobular Emphysema

statistical toolBefore discussing the implications of these observations, it is necessary to consider their reliability. The data in Table 1 are shown because of the possibility that the cases having the background information about alcohol use might not be representative of those for whom this information was not recorded. While the table shows a trend for values to be larger in the group with known history, only one pair of values (prevalence of emphysema) approached statistical significance (p = 0.Q5) using the x2 test.

Continue reading “Disscusion of The Beneficial Effect of Alcohol Consumption on the Prevalence and Extent of Centrilobular Emphysema”

Results of Etiology and Outcome of Community-Acquired Pneumonia in Patients With Diabetes Mellitus

Results of Etiology and Outcome of Community-Acquired Pneumonia in Patients With Diabetes Mellitus

etiologySeven hundred twenty-six patients showing clinical and radiologic findings of community-acquired pneumonia were enrolled in the study; however, 66 patients were subsequently excluded from the study for the following reasons: misdiagnosis at enrollment (n = 59); nosocomial acquisition hospitalization (n = 4); and consent not obtained (n = 3). Thus, 660 patients constituted the final study group. Underlying diseases were found in 324 patients (49%), among which COPD (114 patients), diabetes mellitus (106 patients), and congestive heart disease (58 patients) were the most common.

The subgroup of patients with diabetes mellitus was mainly constituted by patients with type 2 diabetes, which was diagnosed in 100 patients (94%). The mean duration of illness was 8 years, although for 14 patients the diagnosis was established during the present episode of pneumonia. At study entry, the mean plasma glucose level was 238 mg/dL, and the mean hemoglobin A1c value was 8.1%. Diabetes-related complications were common among these patients; thus, 20 patients (19%) had diabetic retinopathy, 18 patients (17%) had diabetic nephropathy, 18 patients (17%) had experienced major mac-rovascular events (eg, ischemic heart disease, stroke, or intermittent claudication), and 5 patients (5%) had peripheral polyneuropathy; for only 56 patients were complications absent. In addition to diet, 59 patients (56%) were receiving treatment with oral agents, and 40 patients (38%) were receiving treatment with insulin (both therapies were simultaneously used in 18 patients); however, during pneumonia 95 patients (90%) needed insulin therapy.

Continue reading “Results of Etiology and Outcome of Community-Acquired Pneumonia in Patients With Diabetes Mellitus”

Brain Stimulation Could Speed Stroke Recovery

Stroke For people who’ve had a stroke, a treatment that involves applying an electric current to the brain may help boost recovery of their mobility, a small clinical trial found.

Stroke is the most common cause of severe, long-term disability. Rehabilitation training, which helps patients re-learn how to use their bodies, can help some patients recover their ability to move. But it is often costly and time-consuming.

The new study looked at 24 patients; each had experienced a stroke that affected his or her ability move a hand and arm. Half of the participants were picked, at random, to receive nine days of rehab paired with a brain-stimulation technique known as transcranial direct current stimulation (tDCS). This method uses electrodes placed on the scalp to deliver constant, low electrical currents to specific areas of the brain. The other patients received a sham control treatment; they were fitted with electrodes but did not receive tDCS. Continue reading “Brain Stimulation Could Speed Stroke Recovery”

The Beneficial Effect of Alcohol Consumption on the Prevalence and Extent of Centrilobular Emphysema

The Beneficial Effect of Alcohol Consumption on the Prevalence and Extent of Centrilobular Emphysema

AlcoholAlcohol is one of the drugs of abuse and, when taken in excess, is clearly capable of producing irreversible damage to several organs, including the liver, brain, and myocardium. Yet it has certain felicitous effects, as a result of which it is used by the majority of the population of this country. Since excessive use has such significant effects, it has long been suspected that moderate consumption also may cause less obvious injury to these or other organs. One organ system which has been considered at risk is the respiratory tract. The susceptibility to tuberculosis and other pulmonary infections is increased, and lung abscesses due to aspiration also are more common.

Continue reading “The Beneficial Effect of Alcohol Consumption on the Prevalence and Extent of Centrilobular Emphysema”